A primetime battle on Monday Night Football features the New Orleans Saints (1-0) traveling to Bank of America Stadium to take on the Carolina Panthers (0-1). Carolina dropped their first game of the season, falling 24-10 to the Atlanta Falcons. On the other sideline, the Saints are looking to stack another win after New Orleans beat the Tennessee Titans, 16-15. The Carolina Panthers have hit the first half game total under in six of their last 10 games at home. The New Orleans Saints have hit the first half game total under in 13 of their last 20 games.

Kickoff from Bank of America Stadium in Charlotte is set for 7:15 p.m. ET. New Orleans is a three-point favorite in the Saints vs. Panthers odds according to SportsLine consensus, while the over/under for total points is 39.5. Before locking in any Panthers vs. Saints picks, make sure to check out the NFL predictions and betting advice from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2023 NFL season on an incredible 163-114 run on top-rated NFL picks that dates back to the 2017 season. It also is on a 17-7 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated Panthers vs. Saints 10,000 times and just revealed its coveted NFL picks and predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Saints vs. Panthers:

  • Panthers vs. Saints spread: Saints -3
  • Panthers vs. Saints over/under: 39.5 points
  • Panthers vs. Saints money line: Saints -160, Panthers +138
  • CAR: 9-9 against the spread since the start of the 2022 season?
  • NO: 7-11 ATS since the start of the 2022 season?
  • Panthers vs. Saints picks: See picks at SportsLine
  • Panthers vs. Saints live stream: fubo (try for free)

Why the Saints can cover

The Saints have several capable playmakers on the field. Receiver Rashid Shaheed has deep speed and the quickness to accelerate past defenders. The Weber State product snagged 28 receptions for 488 yards and two touchdowns as a rookie in 2022. In the season-opener, Shaheed reeled in five grabs with 89 yards and one touchdown.

Receiver Michael Thomas can create separation with ease due to his elite footwork. The three-time Pro Bowler has been hampered by injuries the last two seasons, but was proficient prior to that. He's logged at least 1,000 receiving yards in four of his six seasons. In Week 1, Thomas caught five passes for 61 yards and one touchdown. Tight end Juwan Johnson is an athletic pass-catcher in the seam and has 62 receptions for 742 yards and 11 touchdowns in three seasons with New Orleans.?See who to back at SportsLine.?

Why the Panthers can cover

Young is making his debut in front of the home crowd. The Alabama product was the No. 1 pick in the 2023 NFL Draft and displayed poise and command in his collegiate career. In the season-opener, Young throw for 146 yards with one touchdown and two interceptions. The Panthers, however, have an effective ground attack that can help take pressure off Young.

Carolina piled up 154 rushing yards in Week 1, which ranks fourth in the NFL. Running back Miles Sanders has impressive lateral quickness and totaled 18 carries for 72 yards in the loss to the Falcons. Running back Chuba Hubbard provides Carolina with a change of pace with his breakaway speed. Last week, he had nine carries for 60 yards and ran for six first downs.?See who to back at SportsLine.

How to make Panthers vs. Saints picks

SportsLine's model is leaning Under the total, projecting 39 combined points. The model also says one side of the spread hits in over 50% of simulations. You can only see the model's NFL picks and analysis at SportsLine.?

So who wins Saints vs. Panthers on Monday Night Football, and which side of the spread hits over 50% of the time? Visit SportsLine now to see which side of the Saints vs. Panthers spread to back, all from the model that has returned more than $7,000 on top-rated NFL picks, and find out.